Wearable sweat biosensors Sweat contains a wealth of chemical information that could potentially indicate the body’s deeper biomolecular state. Wearable biosensors have received tremendous attention over the past decade owing to their great potential in predictive analytics and treatment toward personalized medicine. Unlike most reported wearable sensors that mainly track physical activities and vital signs, the new generation of wearable and flexible chemical biosensors enables real-time, continuous and fast detection of accessible biomarkers from the human body, and allows for the collection of large-scale information about the individual's dynamic health status at the molecular level. We target to develop wearable and flexible biosensors toward continuous and non-invasive molecular analysis in sweat, tears, saliva, interstitial fluid, blood, wound exudate as well as exhaled breath.
In vivo devices-brain chip In vivo monitoring of physiology in real time using implanted electrochemical or optical devices or chips wirelessly communicating with personal electronic devices represents the next technology frontier. Being able to continuously read biochemical indicators of physiology would make it possible to realise novel medical interventions with close feedback between the physiological readout and drug delivery, thus effectively treating physiological dysregulation. The challenges with in vivo sensing include sensitivity (low level of analytes), selectivity (biological environment), delivery of readout signal coupled with low power operation, biocompatibility and minimisation of implant-induced foreign body response. We target to develop the implantable brain chip for continuous monitoring of neurochemicals to understand the neuroimmune interface.
Collaborators: Prof Mark Hutchinson, University of Adelaide, Australia Dr Michael Barrata, University of Colorado Boulder, USA Prof Xin Chen, Xi'an Jiaotong University, China Dr Howard Young, National Cancer Institute, NIH USA