Paper is biocompatible with DNA, RNA, proteins, and various clinical samples, favoring its use in diagnostics of biological samples. Paper-based diagnostic tools, such as lateral flow assays, dipstick assays, and microfluidic paper-based analytical devices (µPAD) are emerging as a promising lightweight, disposable and cost-effective format, especially for developing countries and Point-of-Care (POC) testing.
Smartphones are able to bring conventional biomedical tests from specialised laboratories to POC, due to their growing imaging capabilities and significant computing power (about 70% of a typical laptop). The mobile phone devices are capable of quantitative fluorimetric and colorimetric diagnostic assays. In principle, with minimal modifications and/or added hardware, smartphones are capable to carry out assay readouts of a wide variety of diagnostic applications.
We are targeting to development of paper based analytical devices with smartphone readouts, which are able to replace the currently widely used ELISA to realise the digital health management.
1. Z. Luo, et al. G. Liu*, Angewandte Chemie International Edition, 2020, 59,1-7
2. L. Liu, D. Yang, G. Liu*, Biosens. Bioelectron., 2019, 136, 60-75
Prof Bin Liu, Shenzhen University, China
Prof Margaret Morris, UNSW
A/Prof Wen Hu, UNSW
Prof Tony Jun Huang, Duke University, USA
Prof Zhaowei Zhang, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, China